Protein Molecular Weight Markers
ABclonal Technology Raptor Rabbit pAb
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RABL3 Rabbit pAb
Predicted to enable GTP binding activity, GTPase activity, and protein homodimerization activity. Involved in regulation of Ras protein signal transduction and regulation of protein lipidation. Predicted to be active in endomembrane system. Implicated in pancreatic cancer.
ABclonal Technology COQ10B Rabbit pAb
Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion.
ABclonal Technology GPX2 Rabbit pAb
The protein encoded by this gene is a member of the glutathione peroxidase family, which reduces organic hydroperoxides and hydrogen peroxide (H2O2) using glutathione, protecting cells from oxidative damage. This isozyme is mainly expressed in the gastrointestinal tract and liver (in humans), localized in the cytoplasm, and prefers hydrogen peroxide as its substrate. Overexpression is linked to increased differentiation and proliferation in colorectal cancer. It is also a selenoprotein, with selenocysteine (Sec) at its active site, encoded by the UGA codon. The 3 UTR of selenoprotein mRNAs contains a stem-loop structure called the SECIS element, essential for interpreting UGA as Sec, not a stop codon. Alternative splicing variants of this gene have been identified.
ABclonal Technology SRSF3 Rabbit mAb
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.
ABclonal Technology USP13 Rabbit pAb
Enables several functions, including BAT3 complex binding activity, chaperone binding activity, and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway, regulation of cellular catabolic process, and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus.
ABclonal Technology NDUFB3 Rabbit pAb
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene.
ABclonal Technology NLRP12 Rabbit pAb
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
ABclonal Technology IQGAP1 Rabbit mAb
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
ABclonal Technology RAB27B Rabbit pAb
Enables guanyl ribonucleotide binding activity, myosin V binding activity, and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle.
ABclonal Technology NEDD4 Rabbit pAb
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.
Perkin Elmer US LLC Organics High Sensitivity Plastic Nebulizer Tantalum Needle Assembly for PinAAcle 900
The high sensitivity plastic nebulizer provides exceptional sensitivity, precision and corrosion resistance and can be used to aspirate almost all solutions, even those solutions containing a high percentage of acids.
ABclonal Technology GRIA3 Rabbit pAb
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->,GGA, R->,G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
Biotium Primary Antibody Rabbit IgG Fc N2507.RFC CF594 1/EA
Alpaca Anti-Rabbit IgG (Fc) rVHH (N2507 RFC) is a recombinant Alpaca VHH antibody that recognizes the Fc fragment of rabbit IgG and is validated for immunofluorescence Red fluorescent photostable CF594 dye has Ex/Em at 593/614 nm Unit size 500 uL at 0 1 mg/mL
ABclonal Technology CLPTM1 Rabbit mAb
Predicted to be involved in regulation of T cell differentiation in thymus. Located in membrane.